Compound Detail
CHEMBL197633
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Basic Information
| ChEMBL ID | CHEMBL197633 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AUXNPKGXCSBLJK-IUYQGCFVSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
202.2
MW (Da)
-0.98
ALogP
5
HBA
3
HBD
122.2
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 7.0 | 6.7867 | 100.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 100.0 | nM | 7.0 | In vitro binding affinity for NMDA receptor using [3H]-CGP- 39653 | 16190758 |
| Glutamate NMDA receptor | Ki | = | 210.0 | nM | 6.68 | Displacement of [3H]CGP 39653 from NMDA receptor in Sprague-Dawley rat brain syn... | 21220180 |
| Glutamate NMDA receptor | Ki | = | 210.0 | nM | 6.68 | Displacement of [3H]CGP39653 from NMDA receptor in rat cortical membranes | 23954238 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17346858 | 10.1016/j.ejmech.2007.01.013 | Unchecked | 2 |
| 21220180 | 10.1016/j.ejmech.2010.12.020 | Unchecked | 2 |
| 23954238 | 10.1016/j.ejmech.2013.07.010 | Unchecked | 2 |
| 16190758 | 10.1021/jm0504499 | Glutamate NMDA receptor | 1 |
| 16190758 | 10.1021/jm0504499 | Glutamate receptor ionotropic, AMPA | 1 |
| 16190758 | 10.1021/jm0504499 | Glutamate receptor ionotropic, kainate | 1 |
| 21220180 | 10.1016/j.ejmech.2010.12.020 | Glutamate NMDA receptor | 1 |
| 23954238 | 10.1016/j.ejmech.2013.07.010 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine