Assay Detail
Binding
CHEMBL884783
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In vitro binding affinity for NMDA receptor using [3H]-CGP- 39653
10
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.08 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197633 | — | — | 1 | 7.00 |
| CHEMBL197629 | — | — | 2 | 6.68 |
| CHEMBL415461 | — | — | 1 | 6.63 |
| CHEMBL194787 | — | — | 2 | 6.43 |
| CHEMBL370985 | — | — | 1 | 6.29 |
| CHEMBL370566 | — | — | 1 | 5.72 |
| CHEMBL199181 | — | — | 1 | 5.60 |
| CHEMBL421402 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197633 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL197629 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL415461 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL194787 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL370985 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL197629 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL370566 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL199181 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL421402 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL194787 | — | Ki | > | 100000.0 | nM | - |