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Assay Detail

CHEMBL1671445

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Cell Type HEL
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
Montagu A, Roy V, Balzarini J, Snoeck R, Andrei G, Agrofoglio LA.
Eur J Med Chem (2011) 46 : 778 -786
PubMed 21232828 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 6.19 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182 GANCICLOVIR 4.0 1 8.00
CHEMBL31634 BRIVUDINE 2.0 1 7.70
CHEMBL184 ACYCLOVIR 4.0 1 6.40
CHEMBL5314375 CIDOFOVIR 4.0 1 6.10
CHEMBL1669314 1 4.51
CHEMBL1669304 1 4.44
CHEMBL1669310 1 -
CHEMBL1669306 1 -
CHEMBL1669315 1 -
CHEMBL1669316 1 -
CHEMBL1669317 1 -
CHEMBL1669318 1 -
CHEMBL1669305 1 -
CHEMBL1669309 1 -
CHEMBL1643 RIBAVIRIN 4.0 1 -
CHEMBL1669303 1 -
CHEMBL1669307 1 -
CHEMBL1669308 1 -
CHEMBL1669311 1 -
CHEMBL1669312 1 -
CHEMBL1669313 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182 GANCICLOVIR EC50 = 10.0 nM 8.00
CHEMBL31634 BRIVUDINE EC50 = 20.0 nM 7.70
CHEMBL184 ACYCLOVIR EC50 = 400.0 nM 6.40
CHEMBL5314375 CIDOFOVIR EC50 = 800.0 nM 6.10
CHEMBL1669314 EC50 = 31000.0 nM 4.51
CHEMBL1669304 EC50 = 36000.0 nM 4.44
CHEMBL1669310 EC50 = 132000.0 nM -
CHEMBL1669306 EC50 > 10000.0 nM -
CHEMBL1669315 EC50 > 100000.0 nM -
CHEMBL1669316 EC50 > 100000.0 nM -
CHEMBL1669317 EC50 > 100000.0 nM -
CHEMBL1669318 EC50 > 100000.0 nM -
CHEMBL1669305 EC50 > 220000.0 nM -
CHEMBL1669309 EC50 > 240000.0 nM -
CHEMBL1643 RIBAVIRIN EC50 > 250000.0 nM -
CHEMBL1669303 EC50 > 50000.0 nM -
CHEMBL1669307 EC50 > 50000.0 nM -
CHEMBL1669308 EC50 > 50000.0 nM -
CHEMBL1669311 EC50 > 50000.0 nM -
CHEMBL1669312 EC50 > 50000.0 nM -
CHEMBL1669313 EC50 > 50000.0 nM -