Assay Detail
Functional
CHEMBL1671446
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Antiviral activity against thymidine kinase deficient acyclovir-resistant HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.48 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.00 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.10 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 5.22 |
| CHEMBL1669314 | — | — | 1 | 5.07 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.00 |
| CHEMBL1669304 | — | — | 1 | 4.51 |
| CHEMBL1669310 | — | — | 1 | - |
| CHEMBL1669306 | — | — | 1 | - |
| CHEMBL1669315 | — | — | 1 | - |
| CHEMBL1669316 | — | — | 1 | - |
| CHEMBL1669317 | — | — | 1 | - |
| CHEMBL1669318 | — | — | 1 | - |
| CHEMBL1669305 | — | — | 1 | - |
| CHEMBL1669309 | — | — | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
| CHEMBL1669303 | — | — | 1 | - |
| CHEMBL1669307 | — | — | 1 | - |
| CHEMBL1669308 | — | — | 1 | - |
| CHEMBL1669311 | — | — | 1 | - |
| CHEMBL1669312 | — | — | 1 | - |
| CHEMBL1669313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1669314 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1669304 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1669310 | — | EC50 | = | 132000.0 | nM | - |
| CHEMBL1669306 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1669315 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1669316 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1669317 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1669318 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1669305 | — | EC50 | > | 220000.0 | nM | - |
| CHEMBL1669309 | — | EC50 | > | 240000.0 | nM | - |
| CHEMBL1643 | RIBAVIRIN | EC50 | > | 250000.0 | nM | - |
| CHEMBL1669303 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1669307 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1669308 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1669311 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1669312 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1669313 | — | EC50 | > | 50000.0 | nM | - |