Assay Detail
Functional
CHEMBL1676004
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Antimalarial activity against Plasmodium vivax infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium vivax |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.97 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.99 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.59 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.92 |
| CHEMBL1630 | — | — | 1 | 7.85 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.61 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 2.58 | nM | 8.59 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL1630 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 141.5 | nM | 6.85 |