Assay Detail
Binding
CHEMBL1676765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.00 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 7.72 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 6.70 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.05 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 5.96 |
| CHEMBL1672015 | — | — | 1 | 5.80 |
| CHEMBL1672023 | — | — | 1 | 5.72 |
| CHEMBL1165303 | — | — | 1 | 5.66 |
| CHEMBL1164191 | — | — | 1 | 5.60 |
| CHEMBL1165775 | — | — | 1 | 4.80 |
| CHEMBL1672014 | — | — | 1 | - |
| CHEMBL1672016 | — | — | 1 | - |
| CHEMBL1672018 | — | — | 1 | - |
| CHEMBL1672019 | — | — | 1 | - |
| CHEMBL1165387 | — | — | 1 | - |
| CHEMBL1672021 | — | — | 1 | - |
| CHEMBL1672022 | — | — | 1 | - |
| CHEMBL1671870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL43048 | MIDOMAFETAMINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1672015 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1672023 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1165303 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1164191 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1165775 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1672014 | — | IC50 | - | — | - | |
| CHEMBL1672016 | — | IC50 | - | — | - | |
| CHEMBL1672018 | — | IC50 | - | — | - | |
| CHEMBL1672019 | — | IC50 | - | — | - | |
| CHEMBL1165387 | — | IC50 | - | — | - | |
| CHEMBL1672021 | — | IC50 | - | — | - | |
| CHEMBL1672022 | — | IC50 | - | — | - | |
| CHEMBL1671870 | — | IC50 | - | — | - |