Assay Detail
Functional
CHEMBL1677384
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Antimicrobial activity against Trypanosoma cruzi Y infected in rat L6E9 myoblasts assessed as inhibition of [5,6-3H]uracil incorporation after 3 days postinfection by scintillation counter
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical validation of phosphodiesterase C as a chemotherapeutic target in Trypanosoma cruzi, the etiological agent of Chagas' disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.28 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458297 | — | — | 1 | 5.80 |
| CHEMBL460188 | — | — | 1 | 5.77 |
| CHEMBL456366 | — | — | 1 | 5.75 |
| CHEMBL1673316 | — | — | 1 | 5.72 |
| CHEMBL443679 | — | — | 1 | 5.68 |
| CHEMBL456617 | — | — | 1 | 5.64 |
| CHEMBL457663 | — | — | 1 | 5.51 |
| CHEMBL458933 | — | — | 1 | 5.51 |
| CHEMBL1331520 | — | — | 1 | 5.48 |
| CHEMBL456170 | — | — | 1 | 5.48 |
| CHEMBL511686 | — | — | 1 | 5.44 |
| CHEMBL445832 | — | — | 1 | 5.43 |
| CHEMBL1673315 | — | — | 1 | 5.42 |
| CHEMBL455962 | — | — | 1 | 5.42 |
| CHEMBL509969 | — | — | 1 | 5.40 |
| CHEMBL458932 | — | — | 1 | 5.36 |
| CHEMBL1673329 | GK03671 | — | 1 | 5.32 |
| CHEMBL447757 | — | — | 1 | 5.28 |
| CHEMBL1673326 | — | — | 1 | 5.27 |
| CHEMBL513099 | — | — | 1 | 5.25 |
| CHEMBL456618 | — | — | 1 | 5.24 |
| CHEMBL457662 | — | — | 1 | 5.24 |
| CHEMBL456327 | — | — | 1 | 5.21 |
| CHEMBL1673330 | — | — | 1 | 5.19 |
| CHEMBL456826 | — | — | 1 | 5.11 |
| CHEMBL1673311 | — | — | 1 | 5.00 |
| CHEMBL458296 | — | — | 1 | 4.99 |
| CHEMBL1673314 | — | — | 1 | 4.96 |
| CHEMBL1673321 | — | — | 1 | 4.60 |
| CHEMBL1673318 | SCR 01311 | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458297 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL460188 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL456366 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1673316 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL443679 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL456617 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL457663 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL458933 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1331520 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL456170 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL511686 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL445832 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1673315 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL455962 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL509969 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL458932 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1673329 | GK03671 | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL447757 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1673326 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL513099 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL456618 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL457662 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL456327 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1673330 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL456826 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1673311 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL458296 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1673314 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1673321 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1673318 | SCR 01311 | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1673317 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL456574 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL1673312 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL1673313 | — | IC50 | = | 471000.0 | nM | - |
| CHEMBL1673328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1503424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673324 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673323 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1423543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1673322 | — | IC50 | > | 10000.0 | nM | - |