Assay Detail
Binding
CHEMBL1677801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H][Ile5,6]deltorphin 2 from delta opioid receptor in Sprague-Dawley rat brain membrane by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.62 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514774 | — | — | 1 | 9.39 |
| CHEMBL1672083 | — | — | 1 | 9.27 |
| CHEMBL3216476 | — | — | 1 | 9.19 |
| CHEMBL3216936 | — | — | 1 | 9.19 |
| CHEMBL3216475 | — | — | 1 | 9.14 |
| CHEMBL3216716 | — | — | 1 | 9.09 |
| CHEMBL1672086 | — | — | 1 | 8.90 |
| CHEMBL1672090 | — | — | 1 | 8.83 |
| CHEMBL1672091 | — | — | 1 | 8.75 |
| CHEMBL1672087 | — | — | 1 | 8.70 |
| CHEMBL1672084 | — | — | 1 | 7.37 |
| CHEMBL1672085 | — | — | 1 | 7.35 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514774 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1672083 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL3216476 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL3216936 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL3216475 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL3216716 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL1672086 | — | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL1672090 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL1672091 | — | Ki | = | 1.77 | nM | 8.75 |
| CHEMBL1672087 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL1672084 | — | Ki | = | 43.2 | nM | 7.37 |
| CHEMBL1672085 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL70 | MORPHINE | Ki | = | 113.0 | nM | 6.95 |