Assay Detail
ADMET
CHEMBL1678153
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Cytotoxicity activity against human HAEC cells after 24 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HAEC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.47 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673264 | — | — | 1 | 4.96 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 4.89 |
| CHEMBL585145 | — | — | 1 | 4.39 |
| CHEMBL581889 | — | — | 1 | 4.35 |
| CHEMBL419296 | ZOLANTIDINE | — | 1 | 4.12 |
| CHEMBL1079935 | AMPEROZIDE | 2.0 | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673264 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL585145 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL581889 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL419296 | ZOLANTIDINE | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1079935 | AMPEROZIDE | IC50 | = | 83000.0 | nM | 4.08 |