Compound Detail
CHEMBL1079935
AMPEROZIDE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1079935 |
| Name | AMPEROZIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NNAIYOXJNVGUOM-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
2
Known Names
Molecular Properties
401.5
MW (Da)
4.22
ALogP
2
HBA
1
HBD
35.6
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 4 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 6.34 | 6.105 | 455.0 | 2 |
| ADMET CHEMBL612558 | IC50 | 4.08 | 4.08 | 83000.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 4.02 | 4.02 | 95000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 455.0 | nM | 6.34 | Inhibition of human FAAH-mediated hydrolysis of [3H]AEA | 19850474 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 1340.0 | nM | 5.87 | Inhibition of human FAAH | 19850474 |
| ADMET | IC50 | = | 83000.0 | nM | 4.08 | Cytotoxicity activity against human HAEC cells after 24 hrs | 20547797 |
| HepG2 | IC50 | = | 95000.0 | nM | 4.02 | Cytotoxicity activity against human HepG2 cells after 24 hrs | 20547797 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19850474 | 10.1016/j.bmcl.2009.09.086 | Fatty-acid amide hydrolase 1 | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 20547797 | 10.1128/aac.00431-10 | ADMET | 1 |
| 20547797 | 10.1128/aac.00431-10 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine