Assay Detail
ADMET
CHEMBL1679409
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Inhibition of recombinant CYP3A4 after 30 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1671916 | — | — | 1 | 5.85 |
| CHEMBL1671922 | — | — | 1 | - |
| CHEMBL1671921 | — | — | 1 | - |
| CHEMBL1671918 | — | — | 1 | - |
| CHEMBL1671917 | — | — | 1 | - |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | - |
| CHEMBL1671936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1671916 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1671922 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1671921 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1671918 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1671917 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL431770 | ISTRADEFYLLINE | IC50 | > | 40000.0 | nM | - |
| CHEMBL1671936 | — | IC50 | > | 40000.0 | nM | - |