Assay Detail
Binding
CHEMBL1680100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from dopamine D2 receptor low binding site in Sprague-Dawley rat striatum by scintillation counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.20 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 7.27 |
| CHEMBL1672310 | — | — | 1 | 7.25 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.01 |
| CHEMBL1672311 | — | — | 1 | 6.40 |
| CHEMBL1672313 | — | — | 1 | 6.32 |
| CHEMBL1672309 | — | — | 1 | 6.31 |
| CHEMBL1672308 | — | — | 1 | 6.21 |
| CHEMBL1672312 | — | — | 1 | 6.12 |
| CHEMBL53294 | — | — | 1 | 6.09 |
| CHEMBL1672302 | — | — | 1 | 6.07 |
| CHEMBL1672304 | — | — | 1 | 6.00 |
| CHEMBL27559 | — | — | 1 | 5.85 |
| CHEMBL405345 | — | — | 1 | 5.85 |
| CHEMBL1672305 | — | — | 1 | 5.80 |
| CHEMBL106622 | — | — | 1 | 5.75 |
| CHEMBL1672306 | — | — | 1 | 5.62 |
| CHEMBL1672303 | — | — | 1 | 5.52 |
| CHEMBL1672307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1672310 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL53 | APOMORPHINE | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL1672311 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1672313 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL1672309 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL1672308 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL1672312 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL53294 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL1672302 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL1672304 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL27559 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL405345 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1672305 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL106622 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1672306 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1672303 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1672307 | — | Ki | > | 10000.0 | nM | - |