Assay Detail
Binding
CHEMBL1680108
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Inhibition of PI3Kalpha after 15 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.29 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672329 | — | — | 1 | 8.22 |
| CHEMBL1672324 | — | — | 1 | 8.15 |
| CHEMBL1672321 | — | — | 1 | 8.10 |
| CHEMBL1672330 | — | — | 1 | 7.89 |
| CHEMBL1672331 | — | — | 1 | 7.85 |
| CHEMBL1672320 | — | — | 1 | 7.36 |
| CHEMBL1672316 | — | — | 1 | 7.26 |
| CHEMBL1672314 | — | — | 1 | 7.21 |
| CHEMBL1672317 | — | — | 1 | 7.18 |
| CHEMBL1672315 | — | — | 1 | 6.87 |
| CHEMBL1672319 | — | — | 1 | 6.64 |
| CHEMBL1672325 | — | — | 1 | 6.61 |
| CHEMBL1672318 | — | — | 1 | 6.60 |
| CHEMBL1672322 | — | — | 1 | 6.11 |
| CHEMBL1672323 | — | — | 1 | - |
| CHEMBL1672326 | — | — | 1 | - |
| CHEMBL1672327 | — | — | 1 | - |
| CHEMBL1672328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672329 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1672324 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1672321 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1672330 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1672331 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1672320 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1672316 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1672314 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1672317 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1672315 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1672319 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL1672325 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL1672318 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL1672322 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL1672323 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL1672326 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL1672327 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL1672328 | — | IC50 | < | 2.0 | nM | - |