Compound Detail
CHEMBL1672329
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Basic Information
| ChEMBL ID | CHEMBL1672329 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSQDJYYVAYRMKC-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
366.4
MW (Da)
0.47
ALogP
11
HBA
3
HBD
153.9
PSA (Ų)
0.59
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.64
IC50 1 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| A2780 CHEMBL614004 | EC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 6.0 | nM | 8.22 | Inhibition of PI3Kalpha after 15 mins | 24900252 |
| A2780 | EC50 | = | 230.0 | nM | 6.64 | Antiproliferative activity against human A2780 cells | 24900252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900252 | 10.1021/ml1001932 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 24900252 | 10.1021/ml1001932 | A2780 | 1 |
Data from ChEMBL 36 via Core Engine