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Assay Detail

CHEMBL1685517

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Functional
Cytotoxicity against human HCT15 cells
ChEMBL ↗
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-15
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-15 (CHEMBL612263) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo.
Narayan S, Carlson EM, Cheng H, Condon K, Du H, Eckley S, Hu Y, Jiang Y, Kumar V, Lewis BM, Saxton P, Schuck E, Seletsky BM, Tendyke K, Zhang H, Zheng W, Littlefield BA, Towle MJ, Yu MJ.
Bioorg Med Chem Lett (2011) 21 : 1634 -1638
PubMed 21324692 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 9.06 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1683550 — — 1 9.85
CHEMBL1683602 — — 1 9.82
CHEMBL1683546 — — 1 9.80
CHEMBL1683605 — — 1 9.77
CHEMBL1683556 — — 1 9.72
CHEMBL1683554 — — 1 9.70
CHEMBL1683592 — — 1 9.68
CHEMBL1683601 — — 1 9.68
CHEMBL1683596 — — 1 9.66
CHEMBL1683553 — — 1 9.47
CHEMBL1683594 — — 1 9.44
CHEMBL1683603 — — 1 9.43
CHEMBL1683597 — — 1 9.40
CHEMBL1683549 — — 1 9.34
CHEMBL1683551 — — 1 9.34
CHEMBL1683600 — — 1 9.21
CHEMBL1683598 — — 1 9.17
CHEMBL1683599 — — 1 9.11
CHEMBL1683593 — — 1 9.05
CHEMBL1683547 — — 1 8.51
CHEMBL1683604 — — 1 8.27
CHEMBL1683591 — — 1 8.07
CHEMBL159 VINBLASTINE 4.0 1 7.54
CHEMBL53463 DOXORUBICIN 4.0 1 6.81
CHEMBL1683590 ERIBULIN 4.0 1 6.69
CHEMBL1683595 — — 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1683550 — IC50 = 0.14 nM 9.85
CHEMBL1683602 — IC50 = 0.15 nM 9.82
CHEMBL1683546 — IC50 = 0.16 nM 9.80
CHEMBL1683605 — IC50 = 0.17 nM 9.77
CHEMBL1683556 — IC50 = 0.19 nM 9.72
CHEMBL1683554 — IC50 = 0.2 nM 9.70
CHEMBL1683592 — IC50 = 0.21 nM 9.68
CHEMBL1683601 — IC50 = 0.21 nM 9.68
CHEMBL1683596 — IC50 = 0.22 nM 9.66
CHEMBL1683553 — IC50 = 0.34 nM 9.47
CHEMBL1683594 — IC50 = 0.36 nM 9.44
CHEMBL1683603 — IC50 = 0.37 nM 9.43
CHEMBL1683597 — IC50 = 0.4 nM 9.40
CHEMBL1683549 — IC50 = 0.46 nM 9.34
CHEMBL1683551 — IC50 = 0.46 nM 9.34
CHEMBL1683600 — IC50 = 0.62 nM 9.21
CHEMBL1683598 — IC50 = 0.67 nM 9.17
CHEMBL1683599 — IC50 = 0.78 nM 9.11
CHEMBL1683593 — IC50 = 0.89 nM 9.05
CHEMBL1683547 — IC50 = 3.11 nM 8.51
CHEMBL1683604 — IC50 = 5.4 nM 8.27
CHEMBL1683591 — IC50 = 8.57 nM 8.07
CHEMBL159 VINBLASTINE IC50 = 28.5 nM 7.54
CHEMBL53463 DOXORUBICIN IC50 = 153.95 nM 6.81
CHEMBL1683590 ERIBULIN IC50 = 204.0 nM 6.69
CHEMBL1683595 — IC50 - — -
CHEMBL428647 PACLITAXEL IC50 - — -