Assay Detail
Binding
CHEMBL1686237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.42 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1683474 | — | — | 1 | 8.23 |
| CHEMBL1683468 | — | — | 1 | 7.78 |
| CHEMBL1683466 | — | — | 1 | 7.77 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.70 |
| CHEMBL1683475 | — | — | 1 | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL1683469 | — | — | 1 | 7.56 |
| CHEMBL1683471 | — | — | 1 | 7.48 |
| CHEMBL1683472 | — | — | 1 | 7.45 |
| CHEMBL1683473 | — | — | 1 | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.20 |
| CHEMBL1683470 | — | — | 1 | 7.19 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL1683467 | — | — | 1 | 7.16 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1683474 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL1683468 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL1683466 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1683475 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1683469 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL1683471 | — | Ki | = | 33.2 | nM | 7.48 |
| CHEMBL1683472 | — | Ki | = | 35.3 | nM | 7.45 |
| CHEMBL1683473 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1683470 | — | Ki | = | 64.5 | nM | 7.19 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1683467 | — | Ki | = | 68.6 | nM | 7.16 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 630.0 | nM | 6.20 |