Assay Detail
ADMET
CHEMBL1687152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP3A4
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.39 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682888 | — | — | 1 | 5.85 |
| CHEMBL1682891 | — | — | 1 | 5.85 |
| CHEMBL1682895 | — | — | 1 | 5.47 |
| CHEMBL1682893 | — | — | 1 | 5.44 |
| CHEMBL1682899 | — | — | 1 | 5.44 |
| CHEMBL1682892 | — | — | 1 | 5.43 |
| CHEMBL1682903 | — | — | 1 | 5.27 |
| CHEMBL1682894 | — | — | 1 | 5.24 |
| CHEMBL1682900 | — | — | 3 | 5.17 |
| CHEMBL1682896 | — | — | 1 | 5.03 |
| CHEMBL1682887 | — | — | 1 | - |
| CHEMBL1682889 | — | — | 1 | - |
| CHEMBL1682890 | — | — | 1 | - |
| CHEMBL1682897 | — | — | 1 | - |
| CHEMBL1682898 | — | — | 1 | - |
| CHEMBL1682901 | — | — | 1 | - |
| CHEMBL1682902 | — | — | 1 | - |
| CHEMBL1682904 | — | — | 1 | - |
| CHEMBL1682905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682888 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1682891 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1682895 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1682893 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1682899 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1682892 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1682903 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1682894 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1682900 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1682900 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1682896 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1682887 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1682889 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1682890 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL1682897 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682898 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682900 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682904 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1682905 | — | IC50 | > | 10000.0 | nM | - |