Assay Detail
Binding
CHEMBL1687390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL5859) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Development of sulfonamide AKT PH domain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 5.07 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1685065 | PHOSPHATIDYLINOSITOL-TRISPHOSPHATE | — | 1 | 6.30 |
| CHEMBL1685066 | — | — | 1 | 5.80 |
| CHEMBL595583 | — | — | 1 | 5.62 |
| CHEMBL1685055 | — | — | 1 | 5.37 |
| CHEMBL1681823 | — | — | 1 | 5.30 |
| CHEMBL1685049 | — | — | 1 | 5.25 |
| CHEMBL1685058 | — | — | 1 | 5.22 |
| CHEMBL1685053 | — | — | 1 | 5.16 |
| CHEMBL1685050 | — | — | 1 | 5.12 |
| CHEMBL1685057 | — | — | 1 | 5.12 |
| CHEMBL1685064 | — | — | 1 | 5.10 |
| CHEMBL1685039 | — | — | 1 | 5.10 |
| CHEMBL1685042 | — | — | 1 | 5.05 |
| CHEMBL1685043 | — | — | 1 | 5.05 |
| CHEMBL1685041 | — | — | 1 | 5.00 |
| CHEMBL1685038 | — | — | 1 | 4.96 |
| CHEMBL1685044 | — | — | 1 | 4.96 |
| CHEMBL1685051 | — | — | 1 | 4.92 |
| CHEMBL1685040 | — | — | 1 | 4.92 |
| CHEMBL1685060 | — | — | 1 | 4.77 |
| CHEMBL1685063 | — | — | 1 | 4.75 |
| CHEMBL1685056 | — | — | 1 | 4.72 |
| CHEMBL1685059 | — | — | 1 | 4.72 |
| CHEMBL595582 | — | — | 1 | 4.66 |
| CHEMBL1685061 | — | — | 1 | 4.40 |
| CHEMBL611216 | — | — | 1 | 4.39 |
| CHEMBL1685052 | — | — | 1 | - |
| CHEMBL1685054 | — | — | 1 | - |
| CHEMBL1685062 | — | — | 1 | - |
| CHEMBL1685045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1685065 | PHOSPHATIDYLINOSITOL-TRISPHOSPHATE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1685066 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL595583 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1685055 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL1681823 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1685049 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL1685058 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1685053 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1685050 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL1685057 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL1685064 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1685039 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1685043 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1685042 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1685041 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1685038 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1685044 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1685051 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1685040 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1685060 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL1685063 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1685056 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL1685059 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL595582 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL1685061 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL611216 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL593946 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685047 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685046 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL286737 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL282021 | — | Ki | - | — | - | |
| CHEMBL1685037 | — | Ki | - | — | - | |
| CHEMBL1685036 | — | Ki | - | — | - | |
| CHEMBL1685035 | — | Ki | - | — | - | |
| CHEMBL1685034 | — | Ki | - | — | - | |
| CHEMBL1685048 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685033 | — | Ki | - | — | - | |
| CHEMBL1685032 | — | Ki | - | — | - | |
| CHEMBL268439 | — | Ki | - | — | - | |
| CHEMBL1685031 | — | Ki | - | — | - | |
| CHEMBL1685030 | — | Ki | - | — | - | |
| CHEMBL94087 | GLYBUTHIAZOL | Ki | - | — | - | |
| CHEMBL1355299 | SULFAETHIDOLE | Ki | - | — | - | |
| CHEMBL1191 | SULFAMETHIZOLE | Ki | - | — | - | |
| CHEMBL1480108 | — | Ki | - | — | - | |
| CHEMBL1685045 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685062 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685054 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1685052 | — | Ki | > | 50000.0 | nM | - |