Assay Detail
Functional
CHEMBL1687397
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Cytotoxicity against human A2780 cells assessed as intracellular ATP level after 72 hrs by luminometry
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.88 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.36 |
| CHEMBL1685073 | — | — | 2 | 5.77 |
| CHEMBL1685072 | NEOCALYCOPTERON | — | 1 | 5.62 |
| CHEMBL1685074 | CALYFLORENON B | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1685073 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1685073 | — | IC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL1685072 | NEOCALYCOPTERON | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1685074 | CALYFLORENON B | IC50 | = | 11000.0 | nM | 4.96 |