Assay Detail
Functional
CHEMBL1693149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.00 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 8.22 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 7.66 |
| CHEMBL1688855 | — | — | 1 | 7.04 |
| CHEMBL1688857 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1688855 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1688857 | — | IC50 | = | 110.0 | nM | 6.96 |