Assay Detail
ADMET
CHEMBL1693153
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Cytotoxicity against human bone marrow cell by CFU-GM assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Bone marrow cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 7.05 |
| IC90 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 2 | 7.05 |
| CHEMBL481 | IRINOTECAN | 4.0 | 2 | 6.96 |
| CHEMBL84 | TOPOTECAN | 4.0 | 2 | 6.89 |
| CHEMBL1688857 | — | — | 2 | 6.21 |
| CHEMBL1688855 | — | — | 2 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1688857 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1688855 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC90 | = | 700.0 | nM | - |
| CHEMBL84 | TOPOTECAN | IC90 | = | 700.0 | nM | - |
| CHEMBL481 | IRINOTECAN | IC90 | = | 800.0 | nM | - |
| CHEMBL1688855 | — | IC90 | = | 4800.0 | nM | - |
| CHEMBL1688857 | — | IC90 | = | 4500.0 | nM | - |