Assay Detail
Functional
CHEMBL1694198
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Antimalarial activity against Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium vivax |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.52 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.13 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.11 |
| CHEMBL1630 | — | — | 1 | 8.04 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.88 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.39 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.77 |
| CHEMBL221655 | — | — | 1 | 6.56 |
| CHEMBL220692 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL1630 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL221655 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL220692 | — | IC50 | = | 503.0 | nM | 6.30 |