Assay Detail
Functional
CHEMBL1695276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell cycle arrest in human A431 cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by cell sorting method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.50 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1087218 | — | — | 1 | 8.05 |
| CHEMBL1688350 | — | — | 1 | 8.00 |
| CHEMBL203062 | — | — | 1 | 7.89 |
| CHEMBL205166 | — | — | 1 | 7.80 |
| CHEMBL203642 | — | — | 1 | 7.75 |
| CHEMBL204754 | — | — | 1 | 7.75 |
| CHEMBL1688352 | — | — | 1 | 7.75 |
| CHEMBL204710 | — | — | 1 | 7.70 |
| CHEMBL382359 | — | — | 1 | 7.51 |
| CHEMBL1688351 | — | — | 1 | 7.47 |
| CHEMBL381122 | — | — | 1 | 7.31 |
| CHEMBL1688345 | — | — | 1 | 6.28 |
| CHEMBL1087349 | — | — | 1 | 6.21 |
| CHEMBL1688247 | — | — | 1 | - |
| CHEMBL1688248 | — | — | 1 | - |
| CHEMBL1688249 | — | — | 1 | - |
| CHEMBL1688250 | — | — | 1 | - |
| CHEMBL1688344 | — | — | 1 | - |
| CHEMBL1688346 | — | — | 1 | - |
| CHEMBL1688347 | — | — | 1 | - |
| CHEMBL1688348 | — | — | 1 | - |
| CHEMBL1688349 | — | — | 1 | - |
| CHEMBL1688246 | — | — | 1 | - |
| CHEMBL1688356 | — | — | 1 | - |
| CHEMBL1688355 | — | — | 1 | - |
| CHEMBL1688354 | — | — | 1 | - |
| CHEMBL1688353 | — | — | 1 | - |
| CHEMBL1688357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1087218 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1688350 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL203062 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL205166 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL203642 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204754 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1688352 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL204710 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL382359 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1688351 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL381122 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1688345 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1087349 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1688247 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688248 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688249 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688250 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688344 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688346 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688347 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688348 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688349 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688246 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688356 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688355 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688354 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688353 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1688357 | — | EC50 | > | 10000.0 | nM | - |