Assay Detail
Functional
CHEMBL1696828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against R5 tropic HIV1 BaL infected in human TZM-b1 cells after 2 hrs by luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-b1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Reverse transcriptase inhibitors as potential colorectal microbicides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.10 |
| CHEMBL54893 | UC 781 | 1.0 | 1 | 8.03 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL54893 | UC 781 | IC50 | = | 9.34 | nM | 8.03 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | = | 2518.67 | nM | 5.60 |