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Assay Detail

CHEMBL1738447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomyces cerevisiae specifically MEP2 based on MLPCN hits. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1908, AID488812, AID488818]
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Saccharomyces cerevisiae
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Ammonium transporter MEP2 (CHEMBL1741183)
Type SINGLE PROTEIN
Organism Saccharomyces cerevisiae S288c

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.52 5.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1458319 1 5.98
CHEMBL1562104 1 5.91
CHEMBL518292 ISOVELLERAL 1 5.90
CHEMBL1590745 1 5.86
CHEMBL1430795 1 5.64
CHEMBL1344927 1 5.52
CHEMBL1581772 1 5.41
CHEMBL1505372 1 5.17
CHEMBL1578341 1 4.90
CHEMBL1336054 1 4.86
CHEMBL1318350 1 -
CHEMBL1990694 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1458319 EC50 = 1042.0 nM 5.98
CHEMBL1562104 EC50 = 1226.0 nM 5.91
CHEMBL518292 ISOVELLERAL EC50 = 1264.0 nM 5.90
CHEMBL1590745 EC50 = 1381.0 nM 5.86
CHEMBL1430795 EC50 = 2277.0 nM 5.64
CHEMBL1344927 EC50 = 3006.0 nM 5.52
CHEMBL1581772 EC50 = 3857.0 nM 5.41
CHEMBL1505372 EC50 = 6846.0 nM 5.17
CHEMBL1578341 EC50 = 12710.0 nM 4.90
CHEMBL1336054 EC50 = 13690.0 nM 4.86
CHEMBL1318350 EC50 > 33000.0 nM -
CHEMBL1990694 EC50 > 33000.0 nM -