Compound Detail
CHEMBL1458319
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Basic Information
| ChEMBL ID | CHEMBL1458319 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JOVRIPGYHSRFFR-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
302.1
MW (Da)
2.81
ALogP
3
HBA
1
HBD
60.2
PSA (Ų)
0.65
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.98
IC50 1 meas. best 4.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ammonium transporter MEP2 CHEMBL1741183 | EC50 | 5.98 | 5.98 | 1042.0 | 1 |
| Large ribosomal subunit protein eL19A CHEMBL1741172 | EC50 | 5.5 | 5.5 | 3160.0 | 1 |
| Ephrin type-A receptor 4 CHEMBL1293259 | IC50 | 4.87 | 4.87 | 13500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ammonium transporter MEP2 | EC50 | = | 1042.0 | nM | 5.98 | PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomy... | - |
| Large ribosomal subunit protein eL19A | EC50 | = | 3160.0 | nM | 5.5 | PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomy... | - |
| Ephrin type-A receptor 4 | IC50 | = | 13500.0 | nM | 4.87 | PUBCHEM_BIOASSAY: Colorimetric assay for HTS discovery of chemical inhibitors of... | - |
Data from ChEMBL 36 via Core Engine