Assay Detail
Binding
CHEMBL1763071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serotonin transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.10 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762473 | — | — | 1 | 5.68 |
| CHEMBL1762480 | — | — | 1 | 5.58 |
| CHEMBL1762479 | — | — | 1 | 5.36 |
| CHEMBL1762472 | — | — | 1 | 5.35 |
| CHEMBL1762476 | — | — | 1 | 5.24 |
| CHEMBL1762474 | — | — | 1 | 5.17 |
| CHEMBL1762475 | — | — | 1 | 5.00 |
| CHEMBL1762478 | — | — | 1 | 4.36 |
| CHEMBL1762481 | — | — | 1 | 4.16 |
| CHEMBL447183 | — | — | 1 | - |
| CHEMBL1762470 | — | — | 1 | - |
| CHEMBL1762471 | — | — | 1 | - |
| CHEMBL1762477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762473 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1762480 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1762479 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1762472 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1762476 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1762474 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1762475 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1762478 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1762481 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL447183 | — | IC50 | - | — | - | |
| CHEMBL1762470 | — | IC50 | - | — | - | |
| CHEMBL1762471 | — | IC50 | = | - | nM | - |
| CHEMBL1762477 | — | IC50 | - | — | - |