Assay Detail
ADMET
CHEMBL1763135
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Inhibition of CYP3A4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.22 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 6.00 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 5.40 |
| CHEMBL1760338 | — | — | 1 | 5.10 |
| CHEMBL1760205 | — | — | 1 | 4.92 |
| CHEMBL1760206 | — | — | 1 | 4.70 |
| CHEMBL1760200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL10188 | TALNETANT | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1760338 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1760205 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1760206 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1760200 | — | IC50 | > | 15000.0 | nM | - |