Assay Detail
Functional
CHEMBL1763371
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Antiviral activity against HSV1 by plaque reduction assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.58 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.52 |
| CHEMBL528741 | — | — | 1 | 5.89 |
| CHEMBL504574 | — | — | 1 | 5.66 |
| CHEMBL1762444 | — | — | 1 | 5.58 |
| CHEMBL1762448 | — | — | 1 | 5.57 |
| CHEMBL1528228 | — | — | 1 | 5.53 |
| CHEMBL1762449 | — | — | 1 | 5.48 |
| CHEMBL1762441 | — | — | 1 | 5.42 |
| CHEMBL1762458 | — | — | 1 | 5.30 |
| CHEMBL489380 | — | — | 1 | 5.23 |
| CHEMBL1762450 | — | — | 1 | 5.21 |
| CHEMBL1762453 | — | — | 1 | - |
| CHEMBL1762454 | — | — | 1 | - |
| CHEMBL1762455 | — | — | 1 | - |
| CHEMBL375922 | — | — | 1 | - |
| CHEMBL1762457 | — | — | 1 | - |
| CHEMBL505184 | — | — | 1 | - |
| CHEMBL1762459 | — | — | 1 | - |
| CHEMBL1762605 | — | — | 1 | - |
| CHEMBL1762604 | — | — | 1 | - |
| CHEMBL1762460 | — | — | 1 | - |
| CHEMBL1762603 | — | — | 1 | - |
| CHEMBL1762461 | — | — | 1 | - |
| CHEMBL1762462 | — | — | 1 | - |
| CHEMBL546849 | — | — | 1 | - |
| CHEMBL1762600 | — | — | 1 | - |
| CHEMBL586065 | — | — | 1 | - |
| CHEMBL1762601 | — | — | 1 | - |
| CHEMBL1762456 | — | — | 1 | - |
| CHEMBL1762602 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL528741 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL504574 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1762444 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL1762448 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL1528228 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL1762449 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL1762441 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL1762458 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL489380 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1762450 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL1762457 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762440 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL375922 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762455 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762454 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762453 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762452 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762451 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762447 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762446 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762445 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762443 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762442 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL505184 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762459 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762605 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762604 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762460 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762603 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762461 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762462 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL546849 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762600 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL586065 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762601 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762456 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762602 | — | IC50 | > | 25000.0 | nM | - |