Assay Detail
ADMET
CHEMBL1764271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP3A4 in human liver microsomes assessed as formation of 6beta-hydroxy-testosterone using testosterone as substrate by high throughput mass spectrometry preincubated for 30 mins in presence of NADPH
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery and synthesis of potent zwitterionic inhibitors of renin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.69 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761524 | — | — | 1 | 5.85 |
| CHEMBL1761518 | — | — | 1 | 5.85 |
| CHEMBL1761520 | — | — | 1 | 5.85 |
| CHEMBL1761521 | — | — | 1 | 5.80 |
| CHEMBL1761519 | — | — | 1 | 5.62 |
| CHEMBL1761522 | — | — | 1 | 5.62 |
| CHEMBL1761523 | — | — | 1 | 5.25 |
| CHEMBL1761525 | — | — | 1 | - |
| CHEMBL1761530 | — | — | 1 | - |
| CHEMBL1761531 | — | — | 1 | - |
| CHEMBL1761532 | — | — | 1 | - |
| CHEMBL1761533 | — | — | 1 | - |
| CHEMBL1761534 | — | — | 1 | - |
| CHEMBL1761535 | — | — | 1 | - |
| CHEMBL1761536 | — | — | 1 | - |
| CHEMBL1761673 | — | — | 1 | - |
| CHEMBL1761674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761524 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1761518 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1761520 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1761521 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1761519 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1761522 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1761523 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1761525 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761530 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761531 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761533 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761534 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761535 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761536 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761673 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761674 | — | IC50 | > | 50000.0 | nM | - |