Assay Detail
Binding
CHEMBL1764694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.19 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762178 | — | — | 1 | 8.15 |
| CHEMBL1762179 | — | — | 1 | 7.47 |
| CHEMBL1762176 | — | — | 1 | 7.37 |
| CHEMBL1762177 | — | — | 1 | 7.33 |
| CHEMBL1762155 | — | — | 1 | 6.93 |
| CHEMBL1762148 | — | — | 1 | 6.84 |
| CHEMBL1738841 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762178 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1762179 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1762176 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1762177 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1762155 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL1762148 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL1738841 | — | IC50 | = | 600.0 | nM | 6.22 |