Compound Detail

CHEMBL1762155

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CC1(C)C(=O)N(c2ccc(SC(F)(F)F)cc2)C(=O)N1Cc1ccncc1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL1762155
Phase	Preclinical
Structure Type	MOL
InChI Key	VZTJDCKYPWZRFM-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

395.4

MW (Da)

4.44

ALogP

HBA

HBD

53.5

PSA (Å²)

0.57

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 4 meas. best 6.93

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Insulin-like growth factor 1 receptor CHEMBL1957	IC50	6.93	6.6967	117.0	3
MEF CHEMBL614342	IC50	6.55	6.55	282.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Insulin-like growth factor 1 receptor	IC50	=	117.0	nM	6.93	Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulate...	21441024
Insulin-like growth factor 1 receptor	IC50	=	264.0	nM	6.58	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expr...	21441024
Insulin-like growth factor 1 receptor	IC50	=	264.0	nM	6.58	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expr...	21441024
MEF	IC50	=	282.0	nM	6.55	Antiproliferative activity against mouse MEF cells transfected with human IGF1R ...	21441024

PubMed	DOI	Target Context	# Activities
21441024	10.1016/j.bmcl.2011.03.003	Insulin-like growth factor 1 receptor	3
21441024	10.1016/j.bmcl.2011.03.003	MEF	1
21441024	10.1016/j.bmcl.2011.03.003	No relevant target	1
-	10.6019/CHEMBL3301361	No relevant target	1

Data from ChEMBL 36 via Core Engine