Assay Detail
Binding
CHEMBL1764697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.83 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762179 | — | — | 1 | 7.04 |
| CHEMBL1762178 | — | — | 1 | 7.01 |
| CHEMBL1762177 | — | — | 1 | 6.81 |
| CHEMBL1762176 | — | — | 1 | 6.70 |
| CHEMBL1762155 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762179 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1762178 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1762177 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL1762176 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1762155 | — | IC50 | = | 264.0 | nM | 6.58 |