Assay Detail
Functional
CHEMBL1767665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FMLP/CB-stimulated elastase release in human neutrophils treated for 5 mins before FMLP/CB challenge using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as a substrate
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.11 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476958 | — | — | 1 | 6.02 |
| CHEMBL476089 | — | — | 1 | 5.91 |
| CHEMBL476372 | — | — | 1 | 5.84 |
| CHEMBL476362 | — | — | 1 | 5.64 |
| CHEMBL476361 | — | — | 1 | 5.61 |
| CHEMBL476128 | — | — | 1 | 5.53 |
| CHEMBL479236 | — | — | 1 | 5.46 |
| CHEMBL477809 | — | — | 1 | 5.34 |
| CHEMBL476371 | — | — | 1 | 5.29 |
| CHEMBL516722 | — | — | 1 | 5.18 |
| CHEMBL1766569 | — | — | 1 | 5.16 |
| CHEMBL1766568 | — | — | 1 | 4.87 |
| CHEMBL518438 | — | — | 1 | 4.87 |
| CHEMBL478658 | — | — | 1 | 4.79 |
| CHEMBL450543 | — | — | 1 | 4.74 |
| CHEMBL516723 | — | — | 1 | 4.73 |
| CHEMBL515474 | — | — | 1 | 4.72 |
| CHEMBL476337 | — | — | 1 | 4.70 |
| CHEMBL476139 | — | — | 1 | 4.68 |
| CHEMBL476749 | — | — | 1 | 4.67 |
| CHEMBL476997 | — | — | 1 | 4.61 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.02 |
| CHEMBL479254 | — | — | 1 | - |
| CHEMBL478863 | — | — | 1 | - |
| CHEMBL518278 | — | — | 1 | - |
| CHEMBL514199 | — | — | 1 | - |
| CHEMBL516893 | — | — | 1 | - |
| CHEMBL514830 | — | — | 1 | - |
| CHEMBL476088 | — | — | 1 | - |
| CHEMBL516105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476958 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL476089 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL476372 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL476362 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL476361 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL476128 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL479236 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL477809 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL476371 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL516722 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL1766569 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL1766568 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL518438 | — | IC50 | = | 13650.0 | nM | 4.87 |
| CHEMBL478658 | — | IC50 | = | 16170.0 | nM | 4.79 |
| CHEMBL450543 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL516723 | — | IC50 | = | 18610.0 | nM | 4.73 |
| CHEMBL515474 | — | IC50 | = | 18890.0 | nM | 4.72 |
| CHEMBL476337 | — | IC50 | = | 20080.0 | nM | 4.70 |
| CHEMBL476139 | — | IC50 | = | 20850.0 | nM | 4.68 |
| CHEMBL476749 | — | IC50 | = | 21170.0 | nM | 4.67 |
| CHEMBL476997 | — | IC50 | = | 24310.0 | nM | 4.61 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | - | — | - | |
| CHEMBL477388 | — | IC50 | - | — | - | |
| CHEMBL518112 | — | IC50 | - | — | - | |
| CHEMBL476129 | — | IC50 | - | — | - | |
| CHEMBL476959 | — | IC50 | - | — | - | |
| CHEMBL516105 | — | IC50 | - | — | - | |
| CHEMBL476088 | — | IC50 | - | — | - | |
| CHEMBL514830 | — | IC50 | - | — | - | |
| CHEMBL516893 | — | IC50 | - | — | - | |
| CHEMBL514199 | — | IC50 | - | — | - | |
| CHEMBL518278 | — | IC50 | - | — | - | |
| CHEMBL478863 | — | IC50 | - | — | - | |
| CHEMBL479254 | — | IC50 | - | — | - |