Assay Detail
Functional
CHEMBL1767667
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Inhibition of FMLP/CB-stimulated superoxide anion generation in human neutrophils treated for 5 mins before FMLP and CB challenge for 10 mins and 3 mins respectively by spectrophotometer analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.20 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476958 | — | — | 1 | 6.17 |
| CHEMBL476089 | — | — | 1 | 6.05 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | 5.99 |
| CHEMBL476362 | — | — | 1 | 5.80 |
| CHEMBL476372 | — | — | 1 | 5.78 |
| CHEMBL479236 | — | — | 1 | 5.62 |
| CHEMBL476361 | — | — | 1 | 5.58 |
| CHEMBL477809 | — | — | 1 | 5.58 |
| CHEMBL1766569 | — | — | 1 | 5.56 |
| CHEMBL476371 | — | — | 1 | 5.55 |
| CHEMBL479254 | — | — | 1 | 5.54 |
| CHEMBL476128 | — | — | 1 | 5.50 |
| CHEMBL518278 | — | — | 1 | 5.47 |
| CHEMBL476959 | — | — | 1 | 5.47 |
| CHEMBL518112 | — | — | 1 | 5.38 |
| CHEMBL516893 | — | — | 1 | 5.24 |
| CHEMBL516722 | — | — | 1 | 5.22 |
| CHEMBL476129 | — | — | 1 | 5.08 |
| CHEMBL518438 | — | — | 1 | 5.05 |
| CHEMBL516723 | — | — | 1 | 5.02 |
| CHEMBL477388 | — | — | 1 | 4.99 |
| CHEMBL476997 | — | — | 1 | 4.98 |
| CHEMBL476749 | — | — | 1 | 4.90 |
| CHEMBL476337 | — | — | 1 | 4.88 |
| CHEMBL515474 | — | — | 1 | 4.83 |
| CHEMBL476139 | — | — | 1 | 4.82 |
| CHEMBL477389 | — | — | 1 | 4.80 |
| CHEMBL450543 | — | — | 1 | 4.79 |
| CHEMBL478657 | — | — | 1 | 4.78 |
| CHEMBL518576 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476958 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL476089 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL476362 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL476372 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL479236 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL476361 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL477809 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL1766569 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL476371 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL479254 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL476128 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL518278 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL476959 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL518112 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL516893 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL516722 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL476129 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL518438 | — | IC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL516723 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL477388 | — | IC50 | = | 10190.0 | nM | 4.99 |
| CHEMBL476997 | — | IC50 | = | 10480.0 | nM | 4.98 |
| CHEMBL476749 | — | IC50 | = | 12640.0 | nM | 4.90 |
| CHEMBL476337 | — | IC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL515474 | — | IC50 | = | 14770.0 | nM | 4.83 |
| CHEMBL476139 | — | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL477389 | — | IC50 | = | 15810.0 | nM | 4.80 |
| CHEMBL450543 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL478657 | — | IC50 | = | 16570.0 | nM | 4.78 |
| CHEMBL518576 | — | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL514199 | — | IC50 | = | 19390.0 | nM | 4.71 |
| CHEMBL478863 | — | IC50 | = | 19950.0 | nM | 4.70 |
| CHEMBL514830 | — | IC50 | = | 19950.0 | nM | 4.70 |
| CHEMBL518263 | — | IC50 | = | 23520.0 | nM | 4.63 |
| CHEMBL478659 | — | IC50 | = | 25390.0 | nM | 4.59 |
| CHEMBL1766568 | — | IC50 | = | 25570.0 | nM | 4.59 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | - | — | - |