Assay Detail
Functional
CHEMBL1767673
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Antiviral activity against Human enterovirus 71 infected in african green monkey Vero cells assessed as inhibition of viral growth after 24 hrs by Reed-Muench method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus A71 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory properties of 2-substituent-1H-benzimidazole-4-carboxamide derivatives against enteroviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.01 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766666 | — | — | 1 | 6.13 |
| CHEMBL1766669 | — | — | 1 | 5.43 |
| CHEMBL1766670 | — | — | 1 | 4.83 |
| CHEMBL1766673 | — | — | 1 | 4.78 |
| CHEMBL1766672 | — | — | 1 | 4.77 |
| CHEMBL1766667 | — | — | 1 | 4.74 |
| CHEMBL1766671 | — | — | 1 | 4.73 |
| CHEMBL1766665 | — | — | 1 | 4.68 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766666 | — | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL1766669 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL1766670 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1766673 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL1766672 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1766667 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1766671 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1766665 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 2340000.0 | nM | - |