Assay Detail
ADMET
CHEMBL1768087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against rat L6 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.11 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48217 | DAPI | — | 1 | 6.07 |
| CHEMBL3216747 | — | — | 1 | 5.66 |
| CHEMBL3216970 | — | — | 1 | 5.58 |
| CHEMBL3215856 | — | — | 1 | 5.47 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 5.19 |
| CHEMBL3216088 | — | — | 1 | 5.17 |
| CHEMBL3216513 | — | — | 1 | 5.04 |
| CHEMBL3216087 | — | — | 1 | 5.00 |
| CHEMBL1765480 | — | — | 1 | 4.98 |
| CHEMBL3216089 | — | — | 1 | 4.94 |
| CHEMBL1232057 | — | — | 1 | 4.77 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.34 |
| CHEMBL3216971 | — | — | 1 | 4.21 |
| CHEMBL3217178 | — | — | 1 | - |
| CHEMBL3216295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48217 | DAPI | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3216747 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3216970 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3215856 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3216088 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3216513 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3216087 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1765480 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3216089 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL1232057 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3216971 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL3217178 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL3216295 | — | IC50 | > | 169000.0 | nM | - |