Assay Detail
Binding
CHEMBL1769429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminothiazolomorphinans with mixed κ and μ opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.95 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 10.21 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 9.64 |
| CHEMBL1766021 | — | — | 1 | 8.96 |
| CHEMBL1766040 | — | — | 1 | 8.96 |
| CHEMBL299220 | — | — | 1 | 8.89 |
| CHEMBL242756 | — | — | 1 | 8.82 |
| CHEMBL1766039 | — | — | 1 | 8.74 |
| CHEMBL1766023 | — | — | 1 | 8.62 |
| CHEMBL1766022 | — | — | 1 | 8.57 |
| CHEMBL1766024 | — | — | 1 | 8.52 |
| CHEMBL1766043 | — | — | 1 | 8.40 |
| CHEMBL1766025 | — | — | 1 | 8.33 |
| CHEMBL390866 | — | — | 1 | 8.15 |
| CHEMBL1766041 | — | — | 1 | 8.13 |
| CHEMBL1766031 | — | — | 1 | 8.04 |
| CHEMBL1766030 | — | — | 1 | 8.00 |
| CHEMBL1766032 | — | — | 1 | 8.00 |
| CHEMBL1766036 | — | — | 1 | 8.00 |
| CHEMBL1766042 | — | — | 1 | 7.82 |
| CHEMBL1766027 | — | — | 1 | 7.77 |
| CHEMBL1766026 | — | — | 1 | 7.68 |
| CHEMBL1766044 | — | — | 1 | 7.62 |
| CHEMBL1766028 | — | — | 1 | 7.24 |
| CHEMBL1766045 | — | — | 1 | 7.12 |
| CHEMBL1766038 | — | — | 1 | 7.07 |
| CHEMBL1766037 | — | — | 1 | 6.96 |
| CHEMBL1766033 | — | — | 1 | 6.89 |
| CHEMBL390911 | — | — | 1 | 6.82 |
| CHEMBL1766029 | — | — | 1 | 6.75 |
| CHEMBL1766034 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1766021 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1766040 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL299220 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL242756 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1766039 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1766023 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1766022 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1766024 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1766043 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1766025 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL390866 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL1766041 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1766031 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL1766030 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1766032 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL1766036 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1766042 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1766027 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1766026 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1766044 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1766028 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL1766045 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL1766038 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL1766037 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1766033 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL390911 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1766029 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL1766034 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL1766035 | — | Ki | = | 2700.0 | nM | 5.57 |