Assay Detail
Functional
CHEMBL1769436
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Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminothiazolomorphinans with mixed κ and μ opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.92 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 8.77 |
| CHEMBL390866 | — | — | 1 | 7.07 |
| CHEMBL242756 | — | — | 1 | - |
| CHEMBL1766023 | — | — | 1 | - |
| CHEMBL1766024 | — | — | 1 | - |
| CHEMBL1766025 | — | — | 1 | - |
| CHEMBL1766041 | — | — | 1 | - |
| CHEMBL1766043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL390866 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL242756 | — | IC50 | - | — | - | |
| CHEMBL1766023 | — | IC50 | - | — | - | |
| CHEMBL1766024 | — | IC50 | - | — | - | |
| CHEMBL1766025 | — | IC50 | - | — | - | |
| CHEMBL1766041 | — | IC50 | - | — | - | |
| CHEMBL1766043 | — | IC50 | - | — | - |