Assay Detail
ADMET
CHEMBL1769765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.70 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1767164 | GSK-1004723 | 2.0 | 1 | 7.40 |
| CHEMBL639 | AZELASTINE | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1767164 | GSK-1004723 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL639 | AZELASTINE | IC50 | = | 1000.0 | nM | 6.00 |