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Assay Detail

CHEMBL1769805

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type B16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosinase (CHEMBL5346)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.
Sapkota K, Roh E, Lee E, Ha EM, Yang JH, Lee ES, Kwon Y, Kim Y, Na Y.
Bioorg Med Chem (2011) 19 : 2168 -2175
PubMed 21429753 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.16 4.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1766160 1 4.26
CHEMBL1766162 1 4.18
CHEMBL1766156 1 4.05
CHEMBL232202 ARBUTIN 2.0 1 -
CHEMBL1766152 1 -
CHEMBL1766153 1 -
CHEMBL1766154 1 -
CHEMBL1766155 1 -
CHEMBL1766157 1 -
CHEMBL1766158 1 -
CHEMBL1766159 1 -
CHEMBL1766161 1 -
CHEMBL1766163 1 -
CHEMBL1766164 1 -
CHEMBL1766165 1 -
CHEMBL1766166 1 -
CHEMBL1766167 1 -
CHEMBL1766168 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1766160 IC50 = 54700.0 nM 4.26
CHEMBL1766162 IC50 = 66400.0 nM 4.18
CHEMBL1766156 IC50 = 90000.0 nM 4.05
CHEMBL232202 ARBUTIN IC50 = 1550000.0 nM -
CHEMBL1766152 IC50 - -
CHEMBL1766153 IC50 - -
CHEMBL1766154 IC50 - -
CHEMBL1766155 IC50 - -
CHEMBL1766157 IC50 - -
CHEMBL1766158 IC50 - -
CHEMBL1766159 IC50 - -
CHEMBL1766161 IC50 - -
CHEMBL1766163 IC50 - -
CHEMBL1766164 IC50 - -
CHEMBL1766165 IC50 - -
CHEMBL1766166 IC50 - -
CHEMBL1766167 IC50 - -
CHEMBL1766168 IC50 - -