Assay Detail
ADMET
CHEMBL1769915
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Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay
20
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.88 | 5.43 |
| Inhibition | 2 | - | - |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765387 | — | — | 1 | 5.43 |
| CHEMBL1765386 | — | — | 1 | 5.37 |
| CHEMBL1765377 | — | — | 1 | 5.30 |
| CHEMBL1765385 | — | — | 1 | 5.29 |
| CHEMBL1765378 | — | — | 1 | 5.26 |
| CHEMBL1765379 | — | — | 1 | 5.13 |
| CHEMBL1765093 | — | — | 1 | 4.92 |
| CHEMBL1765383 | — | — | 1 | 4.82 |
| CHEMBL455056 | CUCURBITACIN E | — | 1 | 4.82 |
| CHEMBL387737 | CUCURBITACIN I | — | 1 | 4.80 |
| CHEMBL1765384 | — | — | 1 | 4.72 |
| CHEMBL1765517 | — | — | 1 | 4.58 |
| CHEMBL507237 | CUCURBITACIN B | — | 1 | 4.56 |
| CHEMBL493646 | CUCURBITACIN D | — | 1 | 4.11 |
| CHEMBL1765382 | — | — | 1 | 4.09 |
| CHEMBL1765380 | — | — | 1 | - |
| CHEMBL9509 | SILIBININ | 3.0 | 1 | - |
| CHEMBL44814 | CARBON TETRACHLORIDE | -1.0 | 2 | - |
| CHEMBL1765381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765387 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1765386 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL1765377 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1765385 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1765378 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1765379 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL1765093 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1765383 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL455056 | CUCURBITACIN E | IC50 | = | 15250.0 | nM | 4.82 |
| CHEMBL387737 | CUCURBITACIN I | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1765384 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1765517 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL507237 | CUCURBITACIN B | IC50 | = | 27670.0 | nM | 4.56 |
| CHEMBL493646 | CUCURBITACIN D | IC50 | = | 77330.0 | nM | 4.11 |
| CHEMBL1765382 | — | IC50 | = | 80330.0 | nM | 4.09 |
| CHEMBL44814 | CARBON TETRACHLORIDE | Inhibition | - | % | - | |
| CHEMBL9509 | SILIBININ | Activity | - | — | - | |
| CHEMBL1765380 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL44814 | CARBON TETRACHLORIDE | Inhibition | = | 50.0 | % | - |
| CHEMBL1765381 | — | IC50 | = | 226670.0 | nM | - |