Assay Detail
ADMET
CHEMBL1769922
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Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | HSC-T6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.35 | 5.69 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455056 | CUCURBITACIN E | — | 1 | 5.69 |
| CHEMBL1765377 | — | — | 1 | 5.61 |
| CHEMBL1765386 | — | — | 1 | 5.60 |
| CHEMBL1765379 | — | — | 1 | 5.60 |
| CHEMBL1765387 | — | — | 1 | 5.56 |
| CHEMBL1765093 | — | — | 1 | 5.55 |
| CHEMBL1765385 | — | — | 1 | 5.46 |
| CHEMBL1765378 | — | — | 1 | 5.45 |
| CHEMBL387737 | CUCURBITACIN I | — | 1 | 5.44 |
| CHEMBL507237 | CUCURBITACIN B | — | 1 | 5.36 |
| CHEMBL1765383 | — | — | 1 | 5.20 |
| CHEMBL1765384 | — | — | 1 | 5.17 |
| CHEMBL1765382 | — | — | 1 | 5.06 |
| CHEMBL1765517 | — | — | 1 | 4.94 |
| CHEMBL493646 | CUCURBITACIN D | — | 1 | 4.58 |
| CHEMBL1765380 | — | — | 1 | - |
| CHEMBL9509 | SILIBININ | 3.0 | 1 | - |
| CHEMBL1765381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455056 | CUCURBITACIN E | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1765377 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL1765386 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1765379 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL1765387 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL1765093 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL1765385 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1765378 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL387737 | CUCURBITACIN I | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL507237 | CUCURBITACIN B | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL1765383 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL1765384 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1765382 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1765517 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL493646 | CUCURBITACIN D | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1765380 | — | IC50 | = | 256000.0 | nM | - |
| CHEMBL9509 | SILIBININ | Activity | - | — | - | |
| CHEMBL1765381 | — | IC50 | = | 102000.0 | nM | - |