Assay Detail
Binding
CHEMBL1775434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 9.42 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774514 | — | — | 1 | 10.89 |
| CHEMBL1774513 | — | — | 1 | 10.62 |
| CHEMBL1774516 | — | — | 1 | 10.49 |
| CHEMBL1774512 | — | — | 1 | 10.35 |
| CHEMBL1774526 | — | — | 1 | 10.24 |
| CHEMBL1774524 | — | — | 1 | 10.16 |
| CHEMBL1774515 | — | — | 1 | 9.96 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.62 |
| CHEMBL1774520 | — | — | 1 | 9.06 |
| CHEMBL1774517 | — | — | 1 | 8.96 |
| CHEMBL1774525 | — | — | 1 | 8.96 |
| CHEMBL1774531 | — | — | 1 | 8.89 |
| CHEMBL1774530 | — | — | 1 | 8.85 |
| CHEMBL1774518 | — | — | 1 | 8.57 |
| CHEMBL1774527 | — | — | 1 | 8.52 |
| CHEMBL1774519 | — | — | 1 | 8.04 |
| CHEMBL1774529 | — | — | 1 | 7.89 |
| CHEMBL1774521 | — | — | 1 | - |
| CHEMBL1774522 | — | — | 1 | - |
| CHEMBL1774523 | — | — | 1 | - |
| CHEMBL1774528 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774514 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL1774513 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL1774516 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL1774512 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL1774526 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL1774524 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL1774515 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL45 | MELATONIN | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1774520 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL1774517 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1774525 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1774531 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1774530 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1774518 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL1774527 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1774519 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1774529 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1774521 | — | Ki | = | 0.0087 | nM | - |
| CHEMBL1774522 | — | Ki | = | 0.0082 | nM | - |
| CHEMBL1774523 | — | Ki | = | 0.0065 | nM | - |
| CHEMBL1774528 | — | Ki | > | 100.0 | nM | - |