Assay Detail
Binding
CHEMBL1775437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation counting
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 10.43 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774516 | — | — | 1 | 11.00 |
| CHEMBL1774529 | — | — | 1 | 10.96 |
| CHEMBL1774514 | — | — | 1 | 10.96 |
| CHEMBL1774519 | — | — | 1 | 10.92 |
| CHEMBL1774521 | — | — | 1 | 10.85 |
| CHEMBL1774513 | — | — | 1 | 10.74 |
| CHEMBL1774525 | — | — | 1 | 10.70 |
| CHEMBL1774512 | — | — | 1 | 10.66 |
| CHEMBL1774524 | — | — | 1 | 10.47 |
| CHEMBL1774515 | — | — | 1 | 10.46 |
| CHEMBL1774527 | — | — | 1 | 10.43 |
| CHEMBL1774517 | — | — | 1 | 10.08 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.68 |
| CHEMBL1774528 | — | — | 1 | 9.47 |
| CHEMBL1774530 | — | — | 1 | 9.11 |
| CHEMBL1774518 | — | — | 1 | - |
| CHEMBL1774520 | — | — | 1 | - |
| CHEMBL1774522 | — | — | 1 | - |
| CHEMBL1774523 | — | — | 1 | - |
| CHEMBL1774526 | — | — | 1 | - |
| CHEMBL1774531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774516 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL1774529 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL1774514 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL1774519 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL1774521 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL1774513 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL1774525 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL1774512 | — | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL1774524 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL1774515 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL1774527 | — | Ki | = | 0.037 | nM | 10.43 |
| CHEMBL1774517 | — | Ki | = | 0.084 | nM | 10.08 |
| CHEMBL45 | MELATONIN | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL1774528 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL1774530 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL1774518 | — | Ki | = | 0.0085 | nM | - |
| CHEMBL1774520 | — | Ki | = | 0.0067 | nM | - |
| CHEMBL1774522 | — | Ki | = | 0.0065 | nM | - |
| CHEMBL1774523 | — | Ki | = | 0.0096 | nM | - |
| CHEMBL1774526 | — | Ki | = | 0.009 | nM | - |
| CHEMBL1774531 | — | Ki | = | 0.006 | nM | - |