Assay Detail
Functional
CHEMBL1775440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT₂-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.19 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 10.59 |
| CHEMBL1774518 | — | — | 1 | 9.29 |
| CHEMBL1774529 | — | — | 1 | 8.52 |
| CHEMBL1774519 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | EC50 | = | 0.0257 | nM | 10.59 |
| CHEMBL1774518 | — | EC50 | = | 0.5129 | nM | 9.29 |
| CHEMBL1774529 | — | EC50 | = | 3.02 | nM | 8.52 |
| CHEMBL1774519 | — | EC50 | = | 4.467 | nM | 8.35 |