Assay Detail
Binding
CHEMBL1777015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.15 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774157 | — | — | 1 | 8.59 |
| CHEMBL1774031 | — | — | 1 | 8.55 |
| CHEMBL1774160 | — | — | 1 | 8.49 |
| CHEMBL1774154 | — | — | 1 | 8.34 |
| CHEMBL1774163 | — | — | 1 | 8.31 |
| CHEMBL1774158 | — | — | 1 | 8.27 |
| CHEMBL1774156 | — | — | 1 | 8.21 |
| CHEMBL1774161 | — | — | 1 | 8.21 |
| CHEMBL1774162 | — | — | 1 | 8.17 |
| CHEMBL1774164 | — | — | 1 | 8.12 |
| CHEMBL1773083 | — | — | 1 | 8.00 |
| CHEMBL1774159 | — | — | 1 | 7.89 |
| CHEMBL1774165 | — | — | 1 | 7.89 |
| CHEMBL1774166 | — | — | 1 | 7.80 |
| CHEMBL481422 | — | — | 1 | 7.42 |
| CHEMBL1774155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774157 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1774031 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1774160 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1774154 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1774163 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1774158 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1774156 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1774161 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1774162 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1774164 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1773083 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1774159 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1774165 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1774166 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL481422 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1774155 | — | IC50 | > | 50000.0 | nM | - |