Assay Detail
Binding
CHEMBL1777059
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Inhibition of human purified phosphomannose isomerase
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.34 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1314602 | — | — | 1 | 6.00 |
| CHEMBL1725120 | — | — | 1 | 6.00 |
| CHEMBL1406130 | — | — | 1 | 5.89 |
| CHEMBL1701846 | — | — | 1 | 5.75 |
| CHEMBL98386 | — | — | 1 | 5.72 |
| CHEMBL1714438 | — | — | 1 | 5.72 |
| CHEMBL1601716 | — | — | 1 | 5.72 |
| CHEMBL1310318 | — | — | 1 | 5.54 |
| CHEMBL1706034 | — | — | 1 | 5.51 |
| CHEMBL1708710 | — | — | 1 | 5.47 |
| CHEMBL1553163 | — | — | 1 | 5.44 |
| CHEMBL1711919 | — | — | 1 | 5.43 |
| CHEMBL1701599 | — | — | 1 | 5.37 |
| CHEMBL1706897 | — | — | 1 | 5.37 |
| CHEMBL1698123 | — | — | 1 | 5.32 |
| CHEMBL1369613 | — | — | 1 | 5.31 |
| CHEMBL1720377 | — | — | 1 | 5.30 |
| CHEMBL1336959 | — | — | 1 | 5.28 |
| CHEMBL1700715 | — | — | 1 | 5.22 |
| CHEMBL45152 | — | — | 1 | 5.19 |
| CHEMBL1449845 | — | — | 1 | 5.18 |
| CHEMBL1720939 | — | — | 1 | 5.14 |
| CHEMBL1715729 | — | — | 1 | 5.08 |
| CHEMBL1708335 | — | — | 1 | 5.07 |
| CHEMBL1702821 | — | — | 1 | 5.03 |
| CHEMBL74105 | — | — | 1 | 4.85 |
| CHEMBL76175 | — | — | 1 | 4.40 |
| CHEMBL306106 | — | — | 1 | 4.30 |
| CHEMBL1712882 | — | — | 1 | - |
| CHEMBL1733176 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1314602 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1725120 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1406130 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1701846 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL98386 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1714438 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1601716 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1310318 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1706034 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1708710 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1553163 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1711919 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1701599 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1706897 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1698123 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1369613 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1720377 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1336959 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1700715 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL45152 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1449845 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1720939 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1715729 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1708335 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1702821 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL74105 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL76175 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL306106 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1712882 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1733176 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1609086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1725446 | — | IC50 | > | 10000.0 | nM | - |