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Compound Detail

CHEMBL1698123

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O=c1c2ccccc2sn1-c1cccc(Cl)c1

Basic Information

ChEMBL ID CHEMBL1698123
Phase Preclinical
Structure Type MOL
InChI Key BFXLBNPIMRUZFI-UHFFFAOYSA-N
6
Targets
11
Activities
1
Assay Types
0
PK Parameters
17
Publications
0
Known Names

Molecular Properties

261.7
MW (Da)
3.71
ALogP
3
HBA
0
HBD
22.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H8ClNOS
MW 261.73
Aromatic Rings 3
Heavy Atoms 17
NP-Likeness -1.52

Activity Summary

IC50 11 meas. best 5.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hexokinase
CHEMBL1741201
IC50 5.72 5.72 1901.0 1
Mannose-6-phosphate isomerase
CHEMBL2758
IC50 5.46 5.3667 3430.0 3
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
CHEMBL1741212
IC50 5.38 5.03 4180.0 3
Phosphoethanolamine/phosphocholine phosphatase
CHEMBL6113
IC50 5.28 5.28 5200.0 2
Glucose-6-phosphate 1-dehydrogenase
CHEMBL5347
IC50 4.89 4.89 13000.0 1
Phosphomannomutase 2
CHEMBL1741162
IC50 4.22 4.22 59600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hexokinase IC50 = 1901.0 nM 5.72 PUBCHEM_BIOASSAY: Confirmation assay for inhibitors of Trypanosoma brucei hexoki... -
Mannose-6-phosphate isomerase IC50 = 3430.0 nM 5.46 PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting phosphomannose isomerase ... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 4180.0 nM 5.38 PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... -
Mannose-6-phosphate isomerase IC50 = 4800.0 nM 5.32 Inhibition of human purified phosphomannose isomerase 21539312
Mannose-6-phosphate isomerase IC50 = 4800.0 nM 5.32 Inhibition of phosphomannose isomerase (unknown origin) 25124115
Phosphoethanolamine/phosphocholine phosphatase IC50 = 5210.0 nM 5.28 PUBCHEM_BIOASSAY: SAR assay for compounds that inhibit PHOSPHO1. (Class of assay... -
Phosphoethanolamine/phosphocholine phosphatase IC50 = 5200.0 nM 5.28 Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as... 25124115
Glucose-6-phosphate 1-dehydrogenase IC50 = 13000.0 nM 4.89 PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectiv... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 13700.0 nM 4.86 PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point ... -
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase IC50 = 14200.0 nM 4.85 PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct de... -
Phosphomannomutase 2 IC50 = 59600.0 nM 4.22 PUBCHEM_BIOASSAY: Counter screen SAR assay for PMM2 inhibitors via a fluorescenc... -

Literature References

PubMed DOI Target Context # Activities
28159413 10.1016/j.bmcl.2017.01.027 Staphylococcus aureus 4
28159413 10.1016/j.bmcl.2017.01.027 Klebsiella pneumoniae 1
28159413 10.1016/j.bmcl.2017.01.027 Vero C1008 1
28159413 10.1016/j.bmcl.2017.01.027 Plasmodium falciparum 1
28159413 10.1016/j.bmcl.2017.01.027 Candida parapsilosis 1
28159413 10.1016/j.bmcl.2017.01.027 Aspergillus fumigatus 1
28159413 10.1016/j.bmcl.2017.01.027 Trichophyton mentagrophytes 1
28159413 10.1016/j.bmcl.2017.01.027 Sporothrix schenckii 1
28159413 10.1016/j.bmcl.2017.01.027 Cryptococcus neoformans 1
28159413 10.1016/j.bmcl.2017.01.027 Candida albicans 1
21539312 10.1021/jm101401a Mannose-6-phosphate isomerase 1
28159413 10.1016/j.bmcl.2017.01.027 Pseudomonas aeruginosa 1
28159413 10.1016/j.bmcl.2017.01.027 Escherichia coli 1
25124115 10.1016/j.bmcl.2014.07.013 Mannose-6-phosphate isomerase 1
25124115 10.1016/j.bmcl.2014.07.013 Phosphomannomutase 2 1
25124115 10.1016/j.bmcl.2014.07.013 Phosphoethanolamine/phosphocholine phosphatase 1
21539312 10.1021/jm101401a Phosphomannomutase 2 1

Data from ChEMBL 36 via Core Engine