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Assay Detail

CHEMBL3375685

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Binding
Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 mins
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Phosphoethanolamine/phosphocholine phosphatase (CHEMBL6113)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.
Bravo Y, Teriete P, Dhanya RP, Dahl R, Lee PS, Kiffer-Moreira T, Ganji SR, Sergienko E, Smith LH, Farquharson C, Millán JL, Cosford ND.
Bioorg Med Chem Lett (2014) 24 : 4308 -4311
PubMed 25124115 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.76 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1570441 1 6.85
CHEMBL1339149 1 6.30
CHEMBL1713178 1 6.25
CHEMBL1703200 1 6.10
CHEMBL1333250 1 6.09
CHEMBL1369613 1 6.09
CHEMBL45152 1 6.03
CHEMBL1708115 1 5.96
CHEMBL1354431 1 5.96
CHEMBL1720939 1 5.92
CHEMBL1371792 1 5.92
CHEMBL1336959 1 5.89
CHEMBL1737005 1 5.75
CHEMBL1423690 1 5.75
CHEMBL1411202 1 5.64
CHEMBL1700715 1 5.57
CHEMBL1725120 1 5.48
CHEMBL1449845 1 5.40
CHEMBL1701478 1 5.33
CHEMBL1520143 1 5.31
CHEMBL1698123 1 5.28
CHEMBL1706034 1 5.17
CHEMBL1338317 1 5.12
CHEMBL1714438 1 4.96
CHEMBL3322971 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1570441 IC50 = 140.0 nM 6.85
CHEMBL1339149 IC50 = 500.0 nM 6.30
CHEMBL1713178 IC50 = 560.0 nM 6.25
CHEMBL1703200 IC50 = 790.0 nM 6.10
CHEMBL1333250 IC50 = 810.0 nM 6.09
CHEMBL1369613 IC50 = 820.0 nM 6.09
CHEMBL45152 IC50 = 940.0 nM 6.03
CHEMBL1708115 IC50 = 1100.0 nM 5.96
CHEMBL1354431 IC50 = 1100.0 nM 5.96
CHEMBL1720939 IC50 = 1200.0 nM 5.92
CHEMBL1371792 IC50 = 1200.0 nM 5.92
CHEMBL1336959 IC50 = 1300.0 nM 5.89
CHEMBL1737005 IC50 = 1800.0 nM 5.75
CHEMBL1423690 IC50 = 1800.0 nM 5.75
CHEMBL1411202 IC50 = 2300.0 nM 5.64
CHEMBL1700715 IC50 = 2700.0 nM 5.57
CHEMBL1725120 IC50 = 3300.0 nM 5.48
CHEMBL1449845 IC50 = 4000.0 nM 5.40
CHEMBL1701478 IC50 = 4700.0 nM 5.33
CHEMBL1520143 IC50 = 4900.0 nM 5.31
CHEMBL1698123 IC50 = 5200.0 nM 5.28
CHEMBL1706034 IC50 = 6700.0 nM 5.17
CHEMBL1338317 IC50 = 7500.0 nM 5.12
CHEMBL1714438 IC50 = 11000.0 nM 4.96
CHEMBL3322971 IC50 > 10000.0 nM -